Splice was written by director Vincenzo Natali and screenwriters Doug Taylor and Antoinette Terry Bryant. The script was originally meant to follow up Natali's Cube (1997), but the budget and restricted technology hindered the project. In 2007, the project entered active development as a 75% Canadian and 25% French co-production, receiving a budget of $26 million.The director described the film: "Splice is very much about our genetic future and the way science is catching up with much of the fiction out there. "[This] is a serious film and an emotional one. And there's sex... Very unconventional sex. The centerpiece of the movie is a creature which goes through a dramatic evolutionary process. The goal is to create something shocking but also very subtle and completely believable."
In October 2007, actors Adrien Brody and Sarah Polley were cast into the lead roles. Production began the following November in the city of Torono It was aided by Telefilm Canada's funding of US$2.5 million. Filming took place in Toronto and Hamilton, Ontario and concluded in February 2008.
The creatures in the film were created by New York based artist Dan Ouellette of Neurotica Divine.
| Directed by | Vincenzo Natali |
|---|---|
| Produced by | Steve Hoban Guillermo Del Toro Joel Silver |
| Written by | Screenplay: Vincenzo Natali Doug Taylor Antoinette Terry Bryant Story: Vincenzo Natali Antoinette Terry Bryant |
| Starring | Adrien Brody Sarah Polley Delphine Chanéac |
| Music by | Cyrille Aufort |
| Cinematography | Tetsuo Nagata |
| Editing by | Michele Conroy |
| Studio | Dark Castle Entertainment CopperHeart Entertainment Gaumont Telefilm Canada |
| Distributed by | Warner Bros. (UK) Optimum Releasing (UK) |
| Release date(s) | June 4, 2010 |
| Country | United States Canada France |
| Language | English |
| Budget | $26 million |
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